Paraoxonase and prolidase activity in patietns with malignant gliomas [Malign gliomali hastalarda paraoksonaz ve prolidaz aktivitesi]

Aim: we aimed to determine the relationship both paraoxonase and prolidase activitys in the patients with malignant glioma. methods: in this study,serum paraoxonase and prolidase activitys were measured on 25 healthy human and 25 patients with malignant glioma. paraoxonase activity was measured using diethyl-p-nitrophenylphosphate as substrate,as previously described. the prolidase activity was used for measurement of proline by the method proposed by myara et al.,which is a modification of chinard's method (myara et al.,1982). results: the paraoxonase and prolidase activitys were significantly lower in serum of patients with malignant glioma as a whole compared to controls. conclusions: in the current study,the activity paraoxonase and prolidase decreased in the patients with malignant glioma. as a result the paraoxonase and prolidase decreased seems to play a major role in the pathophysiology of malignant glioma. this is the first report on serum paraoxonase and prolidase decreased activities in patients with malignant gliomas.