Medial prefrontal cortex in modifying intermale aggression via oxytocin released in bed nucleus stria terminalis [Stria terminalis bed çekirdeǧinden salgi{dotless}lanan oksitosin yoluyla erkekler-arasi{dotless} saldi{dotless}rganli{dotless}ǧi{dotless}n deǧiştirilmesinde medial prefrontal korteks]

The prefrontal cortex (pfc) plays an important role in the integration of cognitive and affective behaviour and regulating autonomic and neuroendocrine functions. we want to investigate the relationship between destroyed medial prefrontal cortex and bed nucleus of stria terminalis. lesion sites of the medial prefrontal cortex was constructed by input of anodal current. ri test method was employed in this study,and the results showed that attack latency of resident rats was significantly decreased,duration of resident rats showing tail rattling,following or attacking behaviour was significantly increased in mpfc-lesioned rats as compared with sham operated animals. bilateral lesions of the mpfc decreased the fos protein noxytocin-immunoreactive neurones as compared with the sham operated animal. exposure to the ri test induced an increase in oxytocin release within the bnst of lowaggressive rats,whereas oxytocin release did not change from baseline release in highaggressive rats. increased oxytocin release positively correlated with longer attack latencies (r =0.761) and negatively correlated with the lower levels of aggression (r =-0.897). in conclusion,the present study suggests that destruction of the mpfc neurones blocked activation of oxytocin-ir neurones in the bnst during intermale exposure and mpfc-lesioned male rats showed increased aggression. furthermore,oxytocin release within the bnst correlated negatively with intermale aggression.