Clinical features and treatment outcomes of moyamoya disease in 125 patients of Henan,China [Çin'in Henan eyaletindeki 125 moyamoya hastasi üzerinde yapilan klinik özellik analizi ve prognoz takibi]

Objective: we aim to describe clinical features and treatment outcomes of patients with moyamoya disease (mmd) at a single center in china. methods: clinical features of a total of 125 cases of mmd from henan,a provincial capital in china,were retrospectively analyzed. follow-up studies were performed through telephone or regular visits,and recurrent stroke risk was assessed by kaplan-meier analysis. results: the average age at onset of symptoms was 31.6 (range,0.8-74) years,with the female predominance (1.72:1). there is a bimodal age of onset. the initial symptoms included ischemia (64%),hemorrhage (20%) and others (16%). 100 patients received conservative management. the remaining 25 patients received surgical revascularization. the median follow-up period was 28.8 (range,1-192) months. 13 patients were withdrawn. during the follow-up period,7 of 25 patients experienced a second episode of bleeding with a third in 1patient,none of which underwent revascularization. the mortality of rebleeding was 28.6% (2/7). cerebral infarction appeared in 14 of 74 ischemic cases after the initial symptom,with 2 patients dying of large area acute cerebral infarction. 2 of 25 cases who underwent surgical revascularization had ischemic events within 30-day,and another 2 patients died resulting from recurrent infarction caused by surgery. the 5-year risk of recurrent stroke was 42% after the initial symptom for all patients with conservative treatment. conclusion: in the drug-treated group,there was a higher recurrent rate of stroke. these data suggest no potential benefit from surgery in the short term,however,long-time outcome requires a further investigation.