Vagal nerve degeneration and pulmonary artery vasospasm after subarachnoid hemorrhage [Subaraknoid kanama sonrasi{dotless} pulmoner arter vasospazmi{dotless} ve vagal sinir dejenerasyonu]

Objectives: the goal of this study is to investigate and demonstrate whether there is a relationship between the ischemic vagal nerve degeneration and pulmonary artery vasospasm in subarachnoid hemorrhage (sah). methods: animals divided into the 2 groups as control and study groups. in the study group,the animals underwent experimental sah. all of animals sacrificed and their brains and lungs removed. then,the vagal nerve (vn) and pulmonary artery (pa) were examined histologically. the degenerated and normal vn axon density and pa vasospasm indexes (vsi) were counted. the values were compered statistically. results: mean vsi of pulmonary arteries was 0,777±0,048,normal vn axon density estimated as 29700±8500/mm2 and degenerated axon density estimated as 30-5/mm2 in control group. in study group,the mean vsi of pulmonary arteries was 1148±0,090,normal vn axon density estimated as 24500±6600/mm2,degenereted axon density estimated as 5300-750/mm2 in slight pa vasospasm detected animals. but,the mean vsi of pulmonary arteries was 1500±0,120,normal vn axon density estimated as 17300±5500/mm2,degenereted axon density estimated as 11300-3860/mm2 in severe pa vasospasm detected animals. differences were considered to be significant at p< 0.005. conclusion: the degenerated vn axon density may be an important factor in the development of pa vasospasm in sah.