Role of tenoxicam in the prevention of postlaminectomy peridural fibrosis in rats [Ratlarda laminektomi sonrasi{dotless} peridural fibrozisin önlenmesinde tenoksikami{dotless}n rolü]

Aim: the reason behind failed back syndrome in some cases may be peridural fibrosis following spinal surgery. many attempts have been shown to stop formation of peridural fibrosis. nonsteroidal anti-inflammatory drugs (nsaids) inhibit the inflammatory and fibroblastic response. one of the most effective nonsteroidal anti-inflammatory drugs is tenoxicam,an oxicam derivative. this study suggests that topical application of tenoxicam is an effective way of preventing spinal peridural fibrosis developing after laminectomy in rats. material and methods: in this study,20 wistar rats were used. rats were divided into two groups; a control group,and a tenoxicam group. three-level laminectomy was implemented on the rats. rats in the control group only had the laminectomy. in the tenoxicam group,0.5 mg/kg tenoxicam,which was watered down in 0.9% nacl with a factor of 1:10 soaked on cotton,was applied on the dura topically for 5 minutes. three weeks later,rats were killed for histopathologic examination and peridural fibrosis tissue was classified afterwards. results: statistically,it was found that three weeks after surgery,the tenoxicam group had significantly less peridural fibrosis compared to the control group (p<0.05). conclusion: tenoxicam significantly reduced the spinal peridural fibrosis that developed in rats after laminectomy.