Nestin expression in meningiomas of different grades [Farkli{dotless} gradelerdeki meningiomlarda nestin ekspresyonu]

Objective: nestin has been shown to be expressed in some tumor tissues such as glioma,melanoma,ependymoma,rhabdomysarcoma,gastrointestinal stromal tumor and testicular stromal tumor. nestin expression patterns may suggest important relation with the degrees of cancer. in this study,the aim was to demonstrate the expression of nestin in the tumor tissues of patients with different grades meningioma and compare to patients with glioblastoma. methods: in the study,the tumor tissues of 28 meningioma (10 grade i,10 grade ii and 8 grade iii,respectively) and 10 glioblastoma patients were used. nestin immunohistochemistry staining method was applied to the sections taken from paraffin blocks of tumor tissue to determine the nestin immunoreactivity intensity. results: nestin immunoreactivity intensity in the tumor tissues of grade ii and grade iii meningiomas was higher than grade i meningioma group. conclusion: in conclusion,it was determined that high-grade meningiomas exhibited higher nestin immunoreactivity than the low-grade meningioma (grade i). thus,we suggest that the nestin expression may have a contribution to the diagnosis and grading of meningioma tumor tissues.