Research into the acute effects of resveratrol on the traumatic brain injury model in immatur rats [İmmatur ratlarda travmatik beyin hasari{dotless} modelinde resveratrolün akut dönem etkilerinin araşti{dotless}ri{dotless}lmasi{dotless}]

Aim: traumatic brain injury (tbi) is the leading cause of death and disability in childhood. the aim of the present study is to determine the acute effects of resveratrol (res) in the hippocampus and parietal cortex in 7-day-old rat pups subjected to contusion injury. methods: 28 pups were randomly allocated into four groups (per group,n= 7): control group (1),tbi group (2),tbi+50 mg/ kg resveratrol group (3) and tbi+100 mg/ kg resveratrol group (4). single doses of resveratrol were injected intraperitoneally immediately after the induction of tbi. the damage was examined by cresyl violet staining,terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) and active caspase- 3 assay 24 h after trauma. results: treatment with resveratrol significantly ameliorated the trauma induced neuron loss at the ipsi- and contralateral hippocampal brain regions and parietal cortex of rats,other than the ca2 and ca3 regions of the hippocampus in the tbi + 50 mg/ kg resveratrol group. both doses of resveratrol treatment significantly decreased the number of tunel-positive and active caspas-3-positive cells in all ipsi- and contralateral hippocampus and parietal cortexes. a significant difference was found between resveratrol 50 and resveratrol 100 mg/kg in all regions p(< 0.01). conclusions: in conclusion,resveratrol 100 mg/kg especially may be proposed as a highly promising agent for preventing the unfavorable outcomes of traumatic brain damage in young children.