Can royal jelly prevent epidural fibrosis development after laminectomy? An experimental study [Royal jel,laminektomi sonrasi{dotless} epidural fibrozis gelişimini önleyebilirmi? deneysel çali{dotless}şma]

Objective: one of the most important causes of the failed back surgery syndrome is the development of epidural fibrosis. in this study,the effects on the development of epidural fibrosis following experimental laminectomy of royal jelly,of which the positive effects on wound healing are known,were investigated. material and methods: rats were divided into two groups,with eight rats in each group. while only laminectomy was performed in the first group,royal jelly was applied locally in the second group following the laminectomy. vertebral columns were removed 6 weeks later. results: paraffin sections were examined under the light microscope by the neuropathologist and the grade of fibrosis were recorded. each group was compared with the other group according to the level of fibrosis. the fibrosis grade in the group that royal jelly was used was found as significantly lower as compared to the control group. conclusions: although the positive effects of royal jelly on wound healing are known,this study of ours about the effects on the epidural fibrosis development following laminectomy is a first. based on the results of this study,royal jelly decreases the grade of epidural fibrosis in rats following laminectomy. since the royal jelly has no toxic effects on human body,we believe that the phase studies on humans for the medicine form of royal jelly can be carried out.