Behavioral improvement by mouse embryonic stem cell transplantation after spinal cord injury in rats [Si{dotless}çanlarda spinal kord yaralanmasi{dotless} sonrasi{dotless} fare embryonik kök hücre transplantasyonu ile davrani{dotless}şsal gelişme]

Objectives: we transplanted mouse embryonic stem cells to improve functional loss in a rat model of clip-compression spinal cord injury (sci). the mouse embryonic stem cells (mescs) were transplanted to injured cord 7 days after injury. methods: we have treated undifferentiated mouse embryonic stem (es) cells to induce differentiation in vitro into neuron-like cells with good cell viability for use a graft. in this study,we induced spinal cord injury (sci) in rats using clip-compression,and infused mes cells after sci. rats were examined behaviorally using motor and sensory test with neurological assessment. results: motor function of the recipients was gradually improved,whereas little improvement was observed in control rats. this result may suggest that the grafted cells have synaptic connection in the recipient brain. our study revealed that stem cell transplantation can have a positive effect on behavioral recovery and reduction of infarct size in focal ischemic rats. conclusion: we review the application of stem cell transplantation to the spinal cord,emphasizing the use of embryonic stem cells for reconstruction of spinal cord injury. thus,this study provides strong evidence to support that transplantation of mesc could improve functional recovery after sci.