Effects of resveratrol on acute sciatic nerve injury in a rat model [Deneysel sıçan modelinde akut siyatik sinir hasarında resveratrol'ün etkisi]

Aim: this study evaluated the therapeutic efficacy of resveratrol (rvt),a naturally occurring polyphenol,during the management of acute nerve injury in a rat model. materials and methods: a total of 28 rats were divided into trauma,control and low- and high-dose rvt groups (all n = 7). in all three non-control groups,trauma was induced by a medium-pressure aneurysm clip,applied to the sciatic nerve for 30 s. after trauma,the animals were treated with rvt for 7 days,after which nerve tissue samples were obtained from the site of injury for use in histological and stereological analyses. results: there was a significant group difference in myelin thickness. at 50 mg/kg,rvt treatment was associated with increased myelin thickness,but a decrease was observed at 100 mg/kg. conclusion: rvt has a beneficial effect on acute crush injury of the sciatic nerve at a dose of 50 mg/kg. © 2015,ege university press. all rights reserved.