The relationship between the −344C>T polymorphism of gene encoding aldosterone synthase and the prothrombin time in patients with intracerebral hemorrhage [İntraserebral Kanamalı Hastalarda Aldesteron Sentetazı kodlayan -344c>t Polimorfizm Geni ile Protrombin Zamanı Arasındaki İlişkiler]

Objective: gene encoding aldosterone synthase gene (cyp11b2),has been suggested to contribute to stroke. the present study was designed to investigate whether common functional polymorphism −344c>t (rs179998) of the cyp11b2 gene is associated with ischemic stroke (is) and intracerebral hemorrhage (ich) in a russian population. methods: a total 936 unrelated subjects (446 ischemic stroke,57 hemorrhagic stroke patients and 433 healthy controls) from central russia were recruited for this study. dna samples from all study participants were genotyped for the cyp11b2 gene polymorphism through taqman assay. results: no differences in both cyp11b2 allele and genotype frequencies were found between entire patients and control groups. the analysis stratified by stroke subtype and gender was also failed to reveal the association between −344c>t polymorphism and stroke susceptibility. however,the −344tt genotype showed an association with increased prothrombin time in ich patients (p=0.01). conclusion: increased aldosterone levels in carriers of the -344tt genotype directly affect the coagulation system in ich patients,however,the mechanisms,by which aldosterone is associated with an increased prothrombin time are not understood. © 2015,ege university press. all rights reserved.