Febrile infection related epilepsy syndrome (Fires) in adults imitating limbic encephalitis [Erişkinlerde Limbik Ensefaliti Taklit Eden,Ateşli Enfeksiyonla İlişkili Epilepsi Sendromu (AEİES)]

Febrile infection-related epilepsy syndrome (fires) is a rare but devastating condition of the children and only a few adults with similar clinical conditions have been reported so far. two female patients in their thirties presented with explosive onset of intractable epilepsy induced by fever followed by cognitive problems and they were diagnosed as “limbic encephalitis” in the beginning. however,neither paraneoplastic nor infectious etiology was detected despite detailed investigations. their video-eeg monitoring showed multifocal origin of epileptic activity consistent with childhood series of fires. pet studies showed bilateral mesial temporal and frontal lobe hypometabolism,respectively. many antiepileptic drugs and relevant immunotherapeutics were not able to control their seizures. furthermore,ketogenic diet did not provide prominent benefits after this delay in the diagnosis of fires in adult patients. clinical pictures compatible with fires could also be seen in adults and may be misdiagnosed as “limbic encephalitis” without any evidence of paraneoplastic etiology. inclusion of adult cases for pathogenetic and therapeutic investigations for fires may shorten the time to disclose the etiology for this terrible neurological condition. © 2015,ege university press. all rights reserved.