Investigation of mirror movements in parkinson’s disease. Effect of the treatment [Parkinson hastalarında ayna hareketinin araştırılması tedavinin etkisi]

Mirror movements (mm) are unintended movements accompanying voluntary activity in homologous muscles on the opposite side of the body,particularly in distal arm muscles. despite several mechanisms were proposed to explain congenital mm,pathophysiology of mm in parkinson's disease pd) is still unclear and there is not much study to explain it. in our study,investigation of the ethiopathogenesis and frequency of the mm seen in parkinson patients and determining whether or not it improved with treatment were aimed at. here we used focal transcranial magnetic stimulation (tms) to investigate the pathophysiologic substrate of mm in early and advanced stage patients with pd before and after treatment. fifty-two patients with pd and 15 voluntary age-matched healthy people were included. as a result mm were more common in patients with pd when compared with healthy people. mm incidence was increasing parallel to updrs scores in patients with pd. treatment did not affect the frequency of mm in patients with pd. motor threshold of motor cortex contralateral to clinical dominancy was significantly lower in patients with pd. mm are more often in correlation with the severity of pd. relatively increased cortical motor hemisphere activity contralateral to clinically dominancy might be responsible for mm. © 2016,ege university press. all right reserved.