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Interleukin 18 in the CNS
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نویسنده
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alboni s. ,cervia d. ,sugama s. ,conti b.
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منبع
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journal of neuroinflammation - 2010 - دوره : 7 - شماره : 0
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چکیده
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Interleukin (il)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. il-18 and its receptors are expressed in the central nervous system (cns) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. work on il-18 null mice,the localization of the il-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the il-18 system in the cns. this review summarizes current knowledge on the central role of il-18 in health and disease. © 2010 alboni et al; licensee biomed central ltd.
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آدرس
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department of biomedical sciences,university of modena and reggio emilia, Italy, department of environmental sciences,university of tuscia,viterbo, Italy, department of physiology,nippon medical school,1-1-5 sendagi bunkyo-ku,tokyo 113-8602, Japan, molecular and integrative neurosciences department,the scripps research institute,ca, United States
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Authors
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