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Neurotensin is increased in serum of young children with autistic disorder
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نویسنده
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angelidou a. ,francis k. ,vasiadi m. ,alysandratos k. ,zhang b. ,theoharides a. ,lykouras l. ,sideri k. ,kalogeromitros d. ,theoharides t.c.
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منبع
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journal of neuroinflammation - 2010 - دوره : 7 - شماره : 0
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چکیده
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Autism spectrum disorders (asd) are a group of pervasive neurodevelopmental disorders diagnosed in early childhood. they are associated with a set of core symptoms that include disabilities in social interaction skills,verbal and non-verbal communication,as well as repetitive and stereotypic behaviors. there is no definite pathogenetic mechanism or diagnostic tests. many children with asd also have allergic-like symptoms,but test negative implying mast cell activation by non-allergic triggers. we measured by milliplex arrays serum levels of 3 neuropeptides that could stimulate mast cells in children with autistic disorder (n = 19; 16 males and 3 females; mean age 3.0 ± 0.4 years) and healthy,unrelated controls (n = 16; 13 males and 3 females; mean age 3 ± 1.2 years). only neurotensin (nt) was significantly increased from 60.5 ± 6.0 pg/ml in controls to 105.6 ± 12.4 pg/ml in autistic disorder (p = 0.004). there was no statistically significant difference in the serum levels of β-endorphin or substance p (sp). nt could stimulate immune cells,especially mast cells,and/or have direct effects on brain inflammation and asd. © 2010 angelidou et al; licensee biomed central ltd.
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آدرس
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laboratory of molecular immunopharmacology and drug discovery,department of pharmacology and experimental therapeutics,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, second department of psychiatry,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,department of pharmacology and experimental therapeutics,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,department of pharmacology and experimental therapeutics,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,department of pharmacology and experimental therapeutics,tufts university school of medicine,boston,ma,united states,department of biochemistry,tufts university school of medicine,boston,ma, United States, institute of social health insurance (ika),thessaloniki, Greece, second department of psychiatry,attikon general hospital,university of athens medical school,athens, Greece, allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,department of pharmacology and experimental therapeutics,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens,greece,department of biochemistry,tufts university school of medicine,boston,ma,united states,department of internal medicine,tufts university school of medicine and tufts medical center,boston,ma,united states,department of psychiatry,tufts university school of medicine and tufts medical center,boston,ma, United States
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Authors
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