|
|
|
|
Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
|
|
|
|
|
|
|
|
نویسنده
|
zhang b. ,angelidou a. ,alysandratos k.-d. ,vasiadi m. ,francis k. ,asadi s. ,theoharides a. ,sideri k. ,lykouras l. ,kalogeromitros d. ,theoharides t.c.
|
|
منبع
|
journal of neuroinflammation - 2010 - دوره : 7 - شماره : 0
|
|
چکیده
|
Autism spectrum disorders (asd) are neurodevelopmental disorders characterized by difficulties in communication,cognitive and learning deficits,as well as stereotypic behaviors. for the majority of cases there are no reliable biomarkers or distinct pathogenesis. however,increasing evidence indicates asd may be associated with some immune dysregulation,and may have a neuroimmune component. we recently showed that the peptide neurotensin (nt) is increased in autistic children. we now show that nt induces release of extracellular mitochondrial dna (mtdna) that could act as autoimmune trigger. we further show that serum from young autistic patients contains mtdna (n = 20; cytochrome b,p = 0.0002 and 7s,p = 0.006),and anti-mitochondrial antibody type 2 (n = 14; p = 0.001) as compared to normally developing,unrelated controls (n = 12). extracellular blood mtdna and other components may characterize an autistic endophenotype and may contribute to its pathogenesis by activating autoimmune responses. © 2010 zhang et al; licensee biomed central ltd.
|
|
|
|
|
آدرس
|
laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma,united states,department of biochemistry,tufts university school of medicine,boston,ma, United States, laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, second department of psychiatry,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma, United States, department of pediatrics and otorhinolaryngology,institute of social health insurance (ika),thessaloniki, Greece, allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, second department of psychiatry,attikon general hospital,university of athens medical school,athens, Greece, allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens, Greece, laboratory of molecular immunopharmacology and drug discovery,tufts university school of medicine,boston,ma,united states,department of biochemistry,tufts university school of medicine,boston,ma,united states,allergy clinical research center,allergy section,attikon general hospital,university of athens medical school,athens,greece,department of internal medicine,tufts university school of medicine and tufts medical center,boston,ma,united states,department of psychiatry,tufts university school of medicine and tufts medical center,boston,ma, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|