>
Fa   |   Ar   |   En
   Wallerian degeneration: the innate-immune response to traumatic nerve injury  
   
نویسنده rotshenker s.
منبع journal of neuroinflammation - 2011 - دوره : 8 - شماره : 0
چکیده    Traumatic injury to peripheral nerves results in the loss of neural functions. recovery by regeneration depends on the cellular and molecular events of wallerian degeneration that injury induces distal to the lesion site,the domain through which severed axons regenerate back to their target tissues. innate-immunity is central to wallerian degeneration since innate-immune cells,functions and molecules that are produced by immune and non-immune cells are involved. the innate-immune response helps to turn the peripheral nerve tissue into an environment that supports regeneration by removing inhibitory myelin and by upregulating neurotrophic properties. the characteristics of an efficient innate-immune response are rapid onset and conclusion,and the orchestrated interplay between schwann cells,fibroblasts,macrophages,endothelial cells,and molecules they produce. wallerian degeneration serves as a prelude for successful repair when these requirements are met. in contrast,functional recovery is poor when injury fails to produce the efficient innate-immune response of wallerian degeneration. © 2011 rotshenker; licensee biomed central ltd.
کلیدواژه Cytokine; Macrophage; Myelin; Phagocytosis; Wallerian degeneration
آدرس dept. of medical neurobiology,imric,hebrew university,faculty of medicine,jerusalem, Israel
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved