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Neuro-inflammation,blood-brain barrier,seizures and autism
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نویسنده
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theoharides t.c. ,zhang b.
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منبع
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journal of neuroinflammation - 2011 - دوره : 8 - شماره : 0
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چکیده
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Many children with autism spectrum diseases (asd) present with seizure activity,but the pathogenesis is not understood. recent evidence indicates that neuro-inflammation could contribute to seizures. we hypothesize that brain mast cell activation due to allergic,environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation,thus contributing to the development of seizures. treating neuro-inflammation may be useful when anti-seizure medications are ineffective. © 2011 theoharides and zhang; licensee biomed central ltd.
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کلیدواژه
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Autism; Blood-brain barrier; Flavonoids; Mast cells; Neuroinflammation
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آدرس
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molecular immunopharmacology and drug discovery laboratory,department of molecular physiology and pharmacology,tufts university school of medicine,136 harrison avenue,boston,ma,united states,departments of biochemistry,tufts university school of medicine,136 harrison avenue,boston,ma,united states,departments of internal medicine,tufts university school of medicine and tufts medical center,136 harrison avenue,boston,ma,united states,departments of psychiatry,tufts university school of medicine and tufts medical center,136 harrison avenue,boston,ma, United States, molecular immunopharmacology and drug discovery laboratory,department of molecular physiology and pharmacology,tufts university school of medicine,136 harrison avenue,boston,ma,united states,departments of biochemistry,tufts university school of medicine,136 harrison avenue,boston,ma, United States
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Authors
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