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Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease
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نویسنده
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chen s.-y. ,chen t.-f. ,lai l.-c. ,chen j.-h. ,sun y. ,wen l.-l. ,yip p.-k. ,chu y.-m. ,chen y.-c.
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منبع
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journal of neuroinflammation - 2012 - دوره : 9 - شماره : 0
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چکیده
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Background: interleukin 6 (il-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in alzheimer's disease (ad) brain. however,previous studies relating il-6 genetic polymorphisms to ad included few and unrepresentative single nucleotide polymorphisms (snps) and the results were inconsistent.methods: this is a case-control study. a total of 266 patients with ad,aged≧65,were recruited from three hospitals in taiwan (2007-2010). controls (n = 444) were recruited from routine health checkups and volunteers of the hospital during the same period of time. three common il-6 haplotype-tagging snps were selected to assess the association between il-6 polymorphisms and the risk of late-onset ad (load).results: variant carriers of il-6 rs1800796 and rs1524107 were significantly associated with a reduced risk of load [(gg + gc vs. cc): adjusted odds ratio (aor) = 0.64 and (cc + ct vs. tt): aor = 0.60,respectively]. haplotype cat was associated with a decreased risk of load (0 and 1 copy vs. 2 copies: aor = 0.65,95% ci = 0.44-0.95). these associations remained significant in apoe e4 non-carriers only. hypertension significantly modified the association between rs2069837 polymorphisms and the risk of load (p interaction= 0.03).conclusions: il-6 polymorphisms are associated with reduced risk of load,especially in apoe e4 non-carriers. this study identified genetic markers for predicting load in apoe e4 non-carriers. © 2012 chen et al; licensee biomed central ltd.
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کلیدواژه
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Alzheimer's disease; Haplotype; Il-6; Inflammation; SNP
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آدرس
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institute of epidemiology and preventive medicine,college of public health,national taiwan university,taipei, Taiwan, department of neurology,national taiwan university hospital,taipei, Taiwan, graduate institute of physiology,college of medicine,national taiwan university,taipei, Taiwan, institute of epidemiology and preventive medicine,college of public health,national taiwan university,taipei,taiwan,department of geriatrics and gerontology,national taiwan university hospital,taipei, Taiwan, department of neurology,en chu kong hospital,taipei, Taiwan, center of laboratory medicine,en chu kong hospital,taipei, Taiwan, center of neurological medicine,cardinal tien hospital,taipei, Taiwan, department of laboratory medicine,cardinal tien hospital,taipei,taiwan,department of medicine,school of medicine,fu-jen catholic university,taipei, Taiwan, institute of epidemiology and preventive medicine,college of public health,national taiwan university,taipei,taiwan,department of public health,national taiwan university,taipei,taiwan,research center for genes,environment and human health,college of public health,national taiwan university,taipei, Taiwan
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Authors
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