A functional variant in promoter region of platelet-derived growth factor-D is probably associated with intracerebral hemorrhage

Background: platelet-derived growth factor d (pdgf-d) plays an important role in angiogenesis,vessel remodeling,inflammation and repair in response to injury. we hypothesized that genetic variation in pdgfd gene might alter the susceptibility to stroke.findings: we determined the genotypes of a single nucleotide polymorphism (snp) (-858a/c,rs3809021) in 1484 patients with stroke (654 cerebral thrombosis,419 lacunar infarction,411 intracerebral hemorrhage [ich]) and 1528 control subjects from an unrelated chinese han population and followed the stroke patients up for a median of 4.5 years.the -858aa genotype showed significantly increased risk of ich (dominant model: odds ratio [or] 1.29,95% confidence interval [ci] 1.00-1.68,p = 0.05; additive model: or 1.24,95% ci 1.01-1.52,p = 0.04) than wild-type genotype. further analyses showed that -858aa genotype conferred about 2-fold increase in risk of non-hypertensive ich (dominant model: or 2.1,95%ci 1.34-3.29,p = 0.001; additive model: or 1.75,95% ci 1.24-2.46,p = 0.001). after a median follow-up of 4.5 years,-858aa genotype was associated with a reduced risk of ich recurrence (dominant model: adjusted hazard ratio [hr] 0.09,95%ci 0.01-0.74,p = 0.025; additive model: hr 0.21,95% ci 0.04-1.16,p = 0.073) in non-hypertensive patients.conclusions: the -858aa genotype is probably associated with risk for non-hypertensive ich. further studies should be conducted to reveal the role of pdgf-d at various stages of ich development--beneficial,or deleterious. © 2012 bai et al; licensee biomed central ltd.