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   Neuroinflammation and psychiatric illness  
   
نویسنده najjar s. ,pearlman d.m. ,alper k. ,najjar a. ,devinsky o.
منبع journal of neuroinflammation - 2013 - دوره : 10 - شماره : 0
چکیده    Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric illness. while systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders,synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases,neuroimmunological abnormalities occur in classical psychiatric disorders (for example,major depressive,bipolar,schizophrenia,and obsessive-compulsive disorders). investigations into the pathophysiology of these conditions traditionally stressed dysregulation of the glutamatergic and monoaminergic systems,but the mechanisms causing these neurotransmitter abnormalities remained elusive. we review the link between autoimmunity and neuropsychiatric disorders,and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders. understanding how psychosocial,genetic,immunological and neurotransmitter systems interact can reveal pathogenic clues and help target new preventive and symptomatic therapies. © 2013 najjar et al.; licensee biomed central ltd.
کلیدواژه Astrocyte; Bipolar disorder; Cytokines; Depression; Microglia; Neuroinflammation; Obsessive-compulsive disorder; Oxidative stress; Psychoneuroimmunology; Schizophrenia
آدرس department of neurology,new york university school of medicine,550 first avenue,new york,ny 10016,united states,new york university comprehensive epilepsy center,550 first avenue,new york,ny 10016, United States, geisel school of medicine at dartmouth,the dartmouth institute for health policy and clinical practice,30 lafayette street,hb 7252,lebanon,nh 03766,united states,new york university comprehensive epilepsy center,550 first avenue,new york,ny 10016, United States, department of psychiatry,new york university school of medicine,new york,ny, United States, department of pathology,division of neuropathology,new york university school of medicine,550 first avenue,new york,ny 10016, United States, department of neurology,new york university school of medicine,550 first avenue,new york,ny 10016,united states,department of psychiatry,new york university school of medicine,new york,ny,united states,new york university comprehensive epilepsy center,550 first avenue,new york,ny 10016, United States
 
     
   
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