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The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis
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نویسنده
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cravens p.d. ,kieseier b.c. ,hussain r. ,herndon e. ,arellano b. ,ben l.-h. ,timmons b.c. ,castro-rojas c. ,hartung h.-p. ,hemmer b. ,weber m.s. ,zamvil s.s. ,stüve o.
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منبع
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journal of neuroinflammation - 2013 - دوره : 10 - شماره : 0
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چکیده
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Multiple sclerosis (ms) is thought to be a cd4+ t cell mediated autoimmune demyelinating disease of the central nervous system (cns) that is rarely diagnosed during infancy. cellular and molecular mechanisms that confer disease resistance in this age group are unknown. we tested the hypothesis that a differential composition of immune cells within the cns modulates age-associated susceptibility to cns autoimmune disease. c57bl/6 mice younger than eight weeks were resistant to experimental autoimmune encephalomyelitis (eae) following active immunization with myelin oligodendrocyte glycoprotein (mog) peptide (p) 35-55. neonates also developed milder eae after transfer of adult encephalitogenic t cells primed by adult or neonate antigen presenting cells (apc). there was a significant increase in cd45+ hematopoietic immune cells and cd45+ high side scatter granulocytes in the cns of adults,but not in neonates. within the cd45+ immune cell compartment of adults,the accumulation of cd4+ t cells,gr-1+ and gr-1- monocytes and cd11c+ dendritic cells (dc) was identified. a significantly greater percentage of cd19+ b cells in the adult cns expressed mhc ii than neonate cns b cells. only in the adult cns could ifnγ transcripts be detected 10 days post immunization for eae. ifnγ is highly expressed by adult donor cd4+ t cells that are adoptively transferred but not by transferred neonate donor cells. in contrast,il-17 transcripts could not be detected in adult or neonate cns in this eae model,and neither adult nor neonate donor cd4+ t cells expressed il-17 at the time of adoptive transfer. © 2013 cravens et al.; licensee biomed central ltd.
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کلیدواژه
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Age; Antigen presentation; Autoimmunity; Development; EAE; Experimental autoimmune encephalomyelitis; Human; Lymphocytes; Major histocompatibility complex; MHC; Mouse; MS; Multiple sclerosis; Rodent; T helper cells 17
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آدرس
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department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036, United States, department of neurology,heinrich heine university düsseldorf,düsseldorf 40225, Germany, department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036, United States, department of pathology,university of texas,southwestern medical center at dallas,dallas,tx 75390, United States, department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036, United States, department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036, United States, hamon center for therapeutic oncology,university of texas,southwestern medical center at dallas,dallas,tx 75390, United States, department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036, United States, department of neurology,heinrich heine university düsseldorf,düsseldorf 40225, Germany, department of neurology,klinikum rechts der isar,technische universität münchen,münchen 81675, Germany, department of neurology,klinikum rechts der isar,technische universität münchen,münchen 81675,germany,department of neurology,university medical center,georg august university,göttingen 37075,germany,department of neuropathology,university medical center,georg august university,göttingen 37975, Germany, department of neurology,university of california,san francisco,ca 94143,united states,program in immunology,university of california,san francisco,ca 94143, United States, department of neurology and neurotherapeutics,university of texas,southwestern medical center at dallas,dallas,tx 75390-9036,united states,department of neurology,heinrich heine university düsseldorf,düsseldorf 40225,germany,department of neurology,klinikum rechts der isar,technische universität münchen,münchen 81675,germany,neurology section,va north texas health care system,medical service,4500 south lancaster rd,dallas,tx 75216, United States
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Authors
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