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ADAMTS proteoglycanases in the physiological and pathological central nervous system
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نویسنده
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lemarchant s. ,pruvost m. ,montaner j. ,emery e. ,vivien d. ,kanninen k. ,koistinaho j.
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منبع
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journal of neuroinflammation - 2013 - دوره : 10 - شماره : 0
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چکیده
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Adamts-1,-4,-5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (adamts)' family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans. they have been extensively investigated for their involvement in inflammation-induced osteoarthritis,and a growing body of evidence indicates that they may be of key importance in the physiological and pathological central nervous system (cns). in this review,we discuss the deregulated expression of adamts proteoglycanases during acute cns injuries,such as stroke and spinal cord injury. then,we provide new insights on adamts proteoglycanases mediating synaptic plasticity,neurorepair,angiogenesis and inflammation mechanisms. altogether,this review allows us to propose that adamts proteoglycanases may be original therapeutic targets for cns injuries. © 2013 lemarchant et al.; licensee biomed central ltd.
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کلیدواژه
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A disintegrin and metalloproteinase with thrombospondin motifs; Angiogenesis; Chondroitin sulfate proteoglycan; Inflammation; Neurorepair; Proteoglycanases; Spinal cord injury; Stroke; Synaptic plasticity
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آدرس
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department of neurobiology,a. i. virtanen institute for molecular sciences,biocenter kuopio,university of eastern finland,p.o. box 1627,70211 kuopio, Finland, inserm,inserm umr-s 919,serine proteases and pathophysiology of the neurovascular unit,university of caen basse-normandie,gip cyceron,bd h. becquerel,bp 5229,14074 caen cedex, France, neurovascular research laboratory,vall d'hebron research institute,universitat autonoma de barcelona,barcelona, Spain, inserm,inserm umr-s 919,serine proteases and pathophysiology of the neurovascular unit,university of caen basse-normandie,gip cyceron,bd h. becquerel,bp 5229,14074 caen cedex,france,department of neurosurgery,caen university hospital,avenue de la côte de nacre,14000 caen, France, inserm,inserm umr-s 919,serine proteases and pathophysiology of the neurovascular unit,university of caen basse-normandie,gip cyceron,bd h. becquerel,bp 5229,14074 caen cedex, France, department of neurobiology,a. i. virtanen institute for molecular sciences,biocenter kuopio,university of eastern finland,p.o. box 1627,70211 kuopio, Finland, department of neurobiology,a. i. virtanen institute for molecular sciences,biocenter kuopio,university of eastern finland,p.o. box 1627,70211 kuopio,finland,department of oncology,kuopio university hospital,p.o. box 1777,70211 kuopio, Finland
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Authors
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