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Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes
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نویسنده
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crack p.j. ,zhang m. ,morganti-kossmann m.c. ,morris a.j. ,wojciak j.m. ,fleming j.k. ,karve i. ,wright d. ,sashindranath m. ,goldshmit y. ,conquest a. ,daglas m. ,johnston l.a. ,medcalf r.l. ,sabbadini r.a. ,pébay a.
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منبع
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journal of neuroinflammation - 2014 - دوره : 11 - شماره : 0
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چکیده
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Background: lysophosphatidic acid (lpa) is a bioactive phospholipid with a potentially causative role in neurotrauma. blocking lpa signaling with the lpa-directed monoclonal antibody b3/lpathomab is neuroprotective in the mouse spinal cord following injury.findings: here we investigated the use of this agent in treatment of secondary brain damage consequent to traumatic brain injury (tbi). lpa was elevated in cerebrospinal fluid (csf) of patients with tbi compared to controls. lpa levels were also elevated in a mouse controlled cortical impact (cci) model of tbi and b3 significantly reduced lesion volume by both histological and mri assessments. diminished tissue damage coincided with lower brain il-6 levels and improvement in functional outcomes.conclusions: this study presents a novel therapeutic approach for the treatment of tbi by blocking extracellular lpa signaling to minimize secondary brain damage and neurological dysfunction. © 2014 crack et al.; licensee biomed central ltd.
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کلیدواژه
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Anti-LPA antibody; Control cortical impact; Human cerebrospinal fluid; IL-6; Lysophosphatidic acid; Magnetic resonance imaging; Traumatic brain injury
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آدرس
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department of pharmacology,the university of melbourne,parkville, Australia, department of pharmacology,the university of melbourne,parkville, Australia, department of epidemiology and preventive medicine,monash university,melbourne,australia,barrow neurological institute,department of child health,phoenix children's hospital,university of arizona,phoenix,az, United States, division of cardiovascular medicine,university of kentucky college of medicine,lexington,ky, United States, department of biology,san diego state university and lpath inc,4025 sorrento valley blvd,san diego,ca, United States, department of biology,san diego state university and lpath inc,4025 sorrento valley blvd,san diego,ca, United States, department of pharmacology,the university of melbourne,parkville, Australia, florey institute of neuroscience and mental health,parkville,australia,department of anatomy and neuroscience,university of melbourne,parkville, Australia, australian centre for blood diseases,monash university,melbourne, Australia, centre for eye research australia,royal victorian eye and ear hospital and department of ophthalmology,university of melbourne,east melbourne,australia,australian regenerative medicine institute,monash university,clayton, Australia, centre for eye research australia,royal victorian eye and ear hospital and department of ophthalmology,university of melbourne,east melbourne,australia,national trauma research institute,alfred hospital and monash university,melbourne, Australia, australian centre for blood diseases,monash university,melbourne, Australia, florey institute of neuroscience and mental health,parkville,australia,neuroengineering laboratory,department of electrical and electronic engineering,university of melbourne,parkville, Australia, australian centre for blood diseases,monash university,melbourne, Australia, department of biology,san diego state university and lpath inc,4025 sorrento valley blvd,san diego,ca, United States, centre for eye research australia,royal victorian eye and ear hospital and department of ophthalmology,university of melbourne,east melbourne, Australia
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Authors
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