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The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
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نویسنده
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albertsson a.-m. ,zhang x. ,leavenworth j. ,bi d. ,nair s. ,qiao l. ,hagberg h. ,mallard c. ,cantor h. ,wang x.
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منبع
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journal of neuroinflammation - 2014 - دوره : 11 - شماره : 0
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چکیده
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Background: osteopontin (opn) is a highly phosphorylated sialoprotein and a soluble cytokine that is widely expressed in a variety of tissues,including the brain. opn and opn-derived peptides have been suggested to have potential neuroprotective effects against ischemic brain injury,but their role in preterm brain injury is unknown. methods: we used a hypoxia-ischemia (hi)-induced preterm brain injury model in postnatal day 5 mice. opn and opn-derived peptides were given intracerebroventricularly and intranasally before hi. brain injury was evaluated at 7 days after the insults. results: there was a significant increase in endogenous opn mrna and opn protein in the mouse brain after the induction of hi at postnatal day 5. administration of full-length opn protein and thrombin-cleaved opn did not affect preterm brain injury. this was demonstrated with both intracerebroventricular and intranasal administration of opn as well as in opn-deficient mice. interestingly,both n134-153 and c154-198 opn-derived peptides increased the severity of brain injury in this hi-induced preterm brain injury model. conclusions: the neuroprotective effects of opn are age-dependent,and,in contrast to the more mature brain,opn-derived peptides potentiate injury in postnatal day 5 mice. intranasal administration is an efficient way of delivering drugs to the central nervous system (cns) in neonatal mice and is likely to be an easy and noninvasive method of drug delivery to the cns in preterm infants. © albertsson et al.; licensee biomed central ltd.
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کلیدواژه
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Brain injury; Hypoxia; Ischemia; Osteopontin; Preterm
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آدرس
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sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30, Sweden, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30,sweden,the third affiliated hospital of zhengzhou university,department of pediatrics,7 kangfu front st,zhengzhou,450052, China, harvard medical school,department of cancer,immunology and aids,dana-farber cancer institute,1 jimmy fund way,boston,ma 02115,united states,harvard medical school,department of microbiology and immunobiology,division of immunology,77 ave louis pasteur,boston,ma 02115, United States, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30,sweden,the third affiliated hospital of zhengzhou university,department of pediatrics,7 kangfu front st,zhengzhou,450052, China, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30, Sweden, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30,sweden,song jiang central hospital,department of pediatrics,746 songjiang zhongshan west rd,shanghai,201600, China, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30,sweden,sahlgrenska academy at university of gothenburg,perinatal center,department of obstetrics and gynecology,journalvägen 6,41685,gothenburg,sweden,king's college london,king's health partners,st. thomas' hospital,department of perinatal imaging and health,division of imaging sciences and biomedical engineering,london,se1 7eh, United Kingdom, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30, Sweden, harvard medical school,department of cancer,immunology and aids,dana-farber cancer institute,1 jimmy fund way,boston,ma 02115,united states,harvard medical school,department of microbiology and immunobiology,division of immunology,77 ave louis pasteur,boston,ma 02115, United States, sahlgrenska academy at university of gothenburg,perinatal center,department of neuroscience and physiology,box 432,gothenburg,se-405 30,sweden,the third affiliated hospital of zhengzhou university,department of pediatrics,7 kangfu front st,zhengzhou,450052, China
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Authors
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