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Spermine reverses lipopolysaccharide-induced memory deficit in mice
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نویسنده
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frühauf p.k.s. ,porto ineu r. ,tomazi l. ,duarte t. ,mello c.f. ,rubin m.a.
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منبع
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journal of neuroinflammation - 2015 - دوره : 12 - شماره : 1
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چکیده
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Lipopolysaccharide (lps) induces neuroinflammation and memory deficit. since polyamines improve memory in various cognitive tasks,we hypothesized that spermine administration reverses lps-induced memory deficits in an object recognition task in mice. the involvement of the polyamine binding site at the n-methyl-d-aspartate (nmda) receptor and cytokine production in the promnesic effect of spermine were investigated. methods: adult male mice were injected with lps (250 μg/kg,intraperitoneally) and spermine (0.3 to 1 mg/kg,intraperitoneally) or ifenprodil (0.3 to 10 mg/kg,intraperitoneally),or both,and their memory function was evaluated using a novel object recognition task. in addition,cortical and hippocampal cytokines levels were measured by elisa four hours after lps injection. results: spermine increased but ifenprodil decreased the recognition index in the novel object recognition task. spermine,at doses that did not alter memory (0.3 mg/kg,intraperitoneally),reversed the cognitive impairment induced by lps. ifenprodil (0.3 mg/kg,intraperitoneally) reversed the protective effect of spermine against lps-induced memory deficits. however,spermine failed to reverse the lps-induced increase of cortical and hippocampal cytokine levels. conclusions: spermine protects against lps-induced memory deficits in mice by a mechanism that involves glun2b receptors. © frühauf et al.; licensee biomed central.
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کلیدواژه
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Ifenprodil; Memory; Neuroinflammation; NMDA receptor object recognition; Polyamines; Spermine
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آدرس
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federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900, Brazil, federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900, Brazil, federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900, Brazil, federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900, Brazil, federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900,brazil,federal university of santa maria,department of physiology and pharmacology,center of health sciences,santa maria,rs,97105-900, Brazil, federal university of santa maria,graduation program in pharmacology,center of health sciences,santa maria,rs,97105-900,brazil,federal university of santa maria,department of biochemistry and molecular biology,natural and exact sciences center,camobi,santa maria,rs,cep: 97105900, Brazil
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Authors
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