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Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner
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نویسنده
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pan j. ,jin j. ,ge h. ,yin k. ,chen x. ,han l. ,chen y. ,qian l. ,li x. ,xu y.
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منبع
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journal of neuroinflammation - 2015 - دوره : 12 - شماره : 1
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چکیده
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Background: activation of microglia plays a crucial role in immune and inflammatory processes after ischemic stroke. microglia is reported with two opposing activated phenotypes,namely,classic phenotype (m1) and the alternative phenotype (m2). inhibiting m1 while stimulating m2 has been suggested as a potential therapeutic approach in the treatment of stroke. findings: in this study,we indicated that a novel natural anti-oxidant extracted from the chinese plant hopea hainanensis,malibatol a (ma),decreased the infarct size and alleviated the brain injury after mice middle cerebral artery occlusion (mcao). ma inhibited expression inflammatory cytokines in not only mcao mice but also lipopolysaccharide (lps)-stimulated microglia. moreover,treatment of ma decreased m1 markers (cd16,cd32,and cd86) and increased m2 markers (cd206,ym-1) while promoting the activation of nuclear receptor pparγ. conclusions: ma has anti-inflammatory effects in mcao mice in a pparγ-dependent manner,making it a potential candidate for stroke treatment. © pan et al.; licensee biomed central.
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کلیدواژه
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Experimental stroke; Inflammation; M1/M2; Malibatol A; Microglia; PPARγ
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آدرس
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affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008,china,nanjing university,state key laboratory of pharmaceutical biotechnology,22 hankou road,nanjing,jiangsu,210093,china,nanjing university medical school,jiangsu key laboratory for molecular medicine,22 hankou road,nanjing,jiangsu,210093, China, nanjing university,state key laboratory of pharmaceutical biotechnology,22 hankou road,nanjing,jiangsu,210093, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008,china,nanjing university,state key laboratory of pharmaceutical biotechnology,22 hankou road,nanjing,jiangsu,210093,china,nanjing university medical school,jiangsu key laboratory for molecular medicine,22 hankou road,nanjing,jiangsu,210093, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008, China, affiliated drum tower hospital of nanjing university medical school,department of neurology,321 zhongshan road,nanjing,210008,china,nanjing university,state key laboratory of pharmaceutical biotechnology,22 hankou road,nanjing,jiangsu,210093,china,nanjing university medical school,jiangsu key laboratory for molecular medicine,22 hankou road,nanjing,jiangsu,210093,china,diagnosis and therapy center of stroke in jiangsu province,321 zhongshan road,nanjing,jiangsu,210008, China
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