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Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway
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نویسنده
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wang c.-c. ,li h. ,zhang m. ,li x.-l. ,yue l.-t. ,zhang p. ,zhao y. ,wang s. ,duan r.-n. ,li y.-b. ,duan r.-s.
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منبع
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journal of neuroinflammation - 2015 - دوره : 12 - شماره : 1
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چکیده
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Background: il-1β has been shown to play a pivotal role in autoimmunity. cysteinyl aspartate-specific proteinase-1 (caspase-1) inhibitor may be an important drug target for autoimmune diseases. however,the effects of caspase-1 inhibitor on myasthenia gravis (mg) remain undefined. methods: to investigate the effects of caspase-1 inhibitor on experimental autoimmune myasthenia gravis (eamg),an animal model of mg,caspase-1 inhibitor was administered to lewis rats immunized with region 97-116 of the rat achr α subunit (r97-116 peptide) in complete freund's adjuvant. the immunophenotypical characterization by flow cytometry and the levels of autoantibody by elisa were carried out to evaluate the neuroprotective effect of caspase-1 inhibitor. results: we found that caspase-1 inhibitor improved eamg clinical symptom,which was associated with decreased il-17 production by cd4+ t cells and γδ t cells,lower affinity of anti-r97-116 peptide igg. caspase-1 inhibitor decreased expression of cd80,cd86,and mhc class ii on dcs,as well as intracellular il-1β production from dcs. in addition,caspase-1 inhibitor treatment inhibited r97-116 peptide-specific cell proliferation and decreased follicular helper t cells relating to eamg development. conclusions: our results suggest that caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dc il-1-il-17 pathway and provides new evidence that caspase-1 is an important drug target in the treatment of mg and other autoimmune diseases. © 2015 wang et al.
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کلیدواژه
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Caspase-1 inhibitor; Dendric cell; Experimental autoimmune myasthenia gravis; Follicular helper T cell; IL-1β; Th17 cell
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آدرس
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shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,central laboratory,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,school of medicine,jinan,shandong,250012, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China, shandong university,department of neurology,shandong provincial qianfoshan hospital,jinan,shandong,250014, China
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Authors
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