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Thalamic inflammation after brain trauma is associated with thalamo-cortical white matter damage
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نویسنده
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scott g. ,hellyer p.j. ,ramlackhansingh a.f. ,brooks d.j. ,matthews p.m. ,sharp d.j.
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منبع
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journal of neuroinflammation - 2015 - دوره : 12 - شماره : 1
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چکیده
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Background: traumatic brain injury can trigger chronic neuroinflammation,which may predispose to neurodegeneration. animal models and human pathological studies demonstrate persistent inflammation in the thalamus associated with axonal injury,but this relationship has never been shown in vivo. findings: using [11c]-pk11195 positron emission tomography,a marker of microglial activation,we previously demonstrated thalamic inflammation up to 17 years after traumatic brain injury. here,we use diffusion mri to estimate axonal injury and show that thalamic inflammation is correlated with thalamo-cortical tract damage. conclusions: these findings support a link between axonal damage and persistent inflammation after brain injury. © 2015 scott et al.
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کلیدواژه
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Microglia; PK11195; Positron emission tomography; Thalamus; Translocator protein; Traumatic axonal injury; Traumatic brain injury
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آدرس
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imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london, United Kingdom, imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london,united kingdom,king's college london,centre for neuroimaging sciences,institute of psychiatry psychology and neuroscience (ioppn),london, United Kingdom, imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london, United Kingdom, imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london,united kingdom,aarhus university,institute of clinical medicine,aarhus, Denmark, imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london, United Kingdom, imperial college london,division of brain sciences,department of medicine,hammersmith hospital campus,london,united kingdom,computational,cognitive and clinical neuroimaging laboratory,burlington danes bldg.,hammersmith hospital,du cane road,london,w12 0nn, United Kingdom
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Authors
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