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Hypoestoxide reduces neuroinflammation and aα-synuclein accumulation in a mouse model of Parkinson's disease
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نویسنده
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kim c. ,ojo-amaize e. ,spencer b. ,rockenstein e. ,mante m. ,desplats p. ,wrasidlo w. ,adame a. ,nchekwube e. ,oyemade o. ,okogun j. ,chan m. ,cottam h. ,masliah e.
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منبع
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journal of neuroinflammation - 2015 - دوره : 12 - شماره : 1
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چکیده
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Background: deposition of aα-synuclein and neuroinflammation are key pathological features of parkinson's disease (pd). there is no cure for the disease; however,targeting the pathological features might be available to modulate the disease onset and progression. hypoestoxide (he) has been demonstrated as a nf-κb modulator,thereby acting as a potential anti-inflammatory and anti-cancer drug. methods: in order to assess the effect of he in a mouse model of pd,mthy1-aα-syn transgenic mice received intraperitoneal (ip) injections of either vehicle or he (5 mg/kg) daily for 4 weeks. results: treatment of he decreased microgliosis,astrogliosis,and pro-inflammatory cytokine gene expression in aα-syn transgenic mice. he administration also prevented the loss of dopaminergic neurons and ameliorated motor behavioral deficits in the aα-syn transgenic mice,and aα-synuclein pathology was significantly reduced by treatment of he. in addition,increased levels of nuclear phosphorylated nf-κb in the frontal cortex of aα-syn transgenic mice were significantly reduced by he administration. conclusions: these results support the therapeutic potential of he for pd and other aα-synuclein-related diseases. © 2015 kim et al.
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کلیدواژه
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aα-synuclein; Hypoestoxide; Neurodegeneration; Neuroinflammation; NF-ΚB; Parkinson's disease
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آدرس
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university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, immune modulation,inc.,p.o. box 998,bloomington,ca 92316-0998, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, university of california,la jolla,moores cancer center,2880 torrey pines scenic drive,san diego,ca 92037, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093, United States, immune modulation,inc.,p.o. box 998,bloomington,ca 92316-0998, United States, immune modulation,inc.,p.o. box 998,bloomington,ca 92316-0998, United States, immune modulation,inc.,p.o. box 998,bloomington,ca 92316-0998, United States, university of california,la jolla,moores cancer center,2880 torrey pines scenic drive,san diego,ca 92037, United States, university of california,la jolla,moores cancer center,2880 torrey pines scenic drive,san diego,ca 92037,united states,immune modulation,inc.,p.o. box 998,bloomington,ca 92316-0998, United States, university of california,department of neuroscience,la jolla,san diego,ca 92093,united states,university of california,pathology,school of medicine,la jolla,san diego,ca 92093, United States
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Authors
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