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Electronic bypass of spinal lesions: Activation of lower motor neurons directly driven by cortical neural signals
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نویسنده
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li y. ,alam m. ,guo s. ,ting k. ,he j.
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منبع
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journal of neuroengineering and rehabilitation - 2014 - دوره : 11 - شماره : 1
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چکیده
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Background: lower motor neurons in the spinal cord lose supraspinal inputs after complete spinal cord injury,leading to a loss of volitional control below the injury site. extensive locomotor training with spinal cord stimulation can restore locomotion function after spinal cord injury in humans and animals. however,this locomotion is non-voluntary,meaning that subjects cannot control stimulation via their natural intent. a recent study demonstrated an advanced system that triggers a stimulator using forelimb stepping electromyographic patterns to restore quadrupedal walking in rats with spinal cord transection. however,this indirect source of intent may mean that other non-stepping forelimb activities may false-trigger the spinal stimulator and thus produce unwanted hindlimb movements. methods. we hypothesized that there are distinguishable neural activities in the primary motor cortex during treadmill walking,even after low-thoracic spinal transection in adult guinea pigs. we developed an electronic spinal bridge,called motolink
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کلیدواژه
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which detects these neural patterns and triggers a spinal stimulator for hindlimb movement. This hardware can be head-mounted or carried in a backpack. Neural data were processed in real-time and transmitted to a computer for analysis by an embedded processor. Off-line neural spike analysis was conducted to calculate and preset the spike threshold for Motolink hardware. Results: We identified correlated activities of primary motor cortex neurons during treadmill walking of guinea pigs with spinal cord transection. These neural activities were used to predict the kinematic states of the animals. The appropriate selection of spike threshold value enabled the Motolink system to detect the neural intent of walking
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آدرس
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department of rehabilitation sciences,hong kong polytechnic university,hung hom,kowloon, Hong Kong, department of rehabilitation sciences,hong kong polytechnic university,hung hom,kowloon,hong kong,department of neurosurgery,university of california,los angeles,ca, United States, department of rehabilitation sciences,hong kong polytechnic university,hung hom,kowloon, Hong Kong, department of rehabilitation sciences,hong kong polytechnic university,hung hom,kowloon, Hong Kong, department of rehabilitation sciences,hong kong polytechnic university,hung hom,kowloon,hong kong,department of biomedical sciences,city university of hong kong,tat chee avenue,kowloon, Hong Kong
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Authors
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