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Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice
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نویسنده
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yamamoto k. ,kureyama n. ,asano k. ,ikeda t. ,yamatodani a.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 1 - صفحه:118 -120
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چکیده
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We investigated the involvement of substance p (sp) and the neurokinin-1 receptor (nk1r) in the development of radiation-induced hair loss in mice. a dose of 40 gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. a specific nk 1 r antagonist,cp-99,994,significantly delayed radiation-induced hair loss and reduced its severity. furthermore,gamma irradiation induced the expression of preprotachykinin-a,a precursor protein of sp,mrna in irradiated murine skin on the 10th and 30th days after irradiation. these results indicated that gamma irradiation-induced hair loss was mediated by sp via nk1r. ©2010 the japanese pharmacological society.
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کلیدواژه
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Neurokinin-1 receptor; Radiation-induced hair loss; Substance P
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آدرس
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department of medical physics and engineering,graduate school of medicine,osaka university,yamadaoka 1-7,suita,osaka 565-0871, Japan, department of medical physics and engineering,graduate school of medicine,osaka university,yamadaoka 1-7,suita,osaka 565-0871, Japan, department of medical physics and engineering,graduate school of medicine,osaka university,yamadaoka 1-7,suita,osaka 565-0871, Japan, department of accelerator science,institute of scientific and industrial research,osaka university,mihogaoka 8-1,ibaraki,osaka 567-0047, Japan, department of medical physics and engineering,graduate school of medicine,osaka university,yamadaoka 1-7,suita,osaka 565-0871, Japan
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Authors
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