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Tumor necrosis factor-α mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
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نویسنده
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nishioku t. ,matsumoto j. ,dohgu s. ,sumi n. ,miyao k. ,takata f. ,shuto h. ,yamauchi a. ,kataoka y.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 2 - صفحه:251 -254
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چکیده
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The present study was designed to elucidate the involvement of tumor necrosis factor-α (tnf-α) release from activated microglia in the induction of blood-brain barrier (bbb) dysfunction in an in vitro co-culture system with mouse brain capillary endothelial cells (mbec4) and microglia. lipopolysaccharide (lps)-activated microglia increased the permeability of mbec4 cells to sodium-fluorescein,and this hyper-permeability was blocked by a neutralizing antibody against tnf-α . lps stimulated microglia to facilitate tnf-α release. these findings suggested that tnf-α released from activated microglia is attributable to bbb dysfunction. ©2010 the japanese pharmacological society.
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کلیدواژه
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Blood-brain barrier; Microglia; Tumor necrosis factor-α (TNF-α)
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آدرس
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department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180,japan,bbb laboratory,pharmaco-cell co.,ltd.,nagasaki 852-8523, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180, Japan, department of pharmaceutical care and health sciences,faculty of pharmaceutical sciences,fukuoka university,8-19-1 nanakuma,jonan-ku,fukuoka 814-0180,japan,bbb laboratory,pharmaco-cell co.,ltd.,nagasaki 852-8523, Japan
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Authors
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