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The protective effect of radicicol against renal ischemia-reperfusion injury in mice
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نویسنده
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sonoda h. ,prachasilchai w. ,kondo h. ,yokota-ikeda n. ,oshikawa s. ,ito k. ,ikeda m.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 2 - صفحه:242 -246
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چکیده
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Overexpression of heat shock protein 70 kda (hsp70) is known to confer cellular protection against ischemia-reperfusion (i/r) injury. radicicol,a hsp90 inhibitor,has been reported to induce the expression of hsp70 protein. here we studied whether radicicol attenuated renal i/r injury in vivo. treatment of mice with radicicol ameliorated renal i/r injury and increased renal hsp70 mrna and protein. administration of radicicol with quercetin,an inhibitor of hsp70 induction,eliminated the renoprotective effect of radicicol. our results suggest that the up-regulation of renal hsp70 protein by radicicol leads to a novel drug therapy against renal i/r injury. ©2010 the japanese pharmacological society.
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کلیدواژه
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Heat shock protein 70 kDa (HSP70); Radicicol; Renal ischemia-reperfusion injury
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آدرس
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department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan, department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan, department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan, department of internal medicine,miyazaki prefectural miyazaki hospital,kita-takamatsu 5-30,miyazaki 880-8510, Japan, department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan, department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan, department of veterinary pharmacology,faculty of agriculture,university of miyazaki,miyazaki 889-2192, Japan
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Authors
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