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Co-operative effect between γ-aminobutyric acid A receptors and central-type benzodiazepine receptors on amylase release in rat parotid acinar cells
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نویسنده
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okubo m. ,kawaguchi m.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 2 - صفحه:247 -250
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چکیده
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We investigated the inhibitory role of γ-aminobutyric acid a (gabaa) receptors on amylase release and the evidence for functional coupling with central-type benzodiazepine receptors in rat parotid acinar cells. muscimol and gaba decreased isoprenaline-induced amylase release. this effect was blocked by bicuculline,a gabaa-receptor antagonist,and enhanced by clonazepam,a central-type benzodiazepine-receptor agonist,and diazepam,a central- and peripheral-type benzodiazepine-receptor agonist. although bicuculline completely blocked the combination effect of gaba a-receptor agonist and clonazepam,it did not completely block the combination effect with diazepam. these results suggest that protein secretion is suppressively regulated by gabaa receptors coupled with central-type benzodiazepine receptors. ©2010 the japanese pharmacological society.
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کلیدواژه
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γ-aminobutyric acid A receptor; Amylase release; Parotid gland
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آدرس
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department of pharmacology,tokyo dental college,1-2-2 masago,mihama-ku,chiba 261-8502, Japan, department of pharmacology,tokyo dental college,1-2-2 masago,mihama-ku,chiba 261-8502, Japan
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Authors
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