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Cellular Ca2+ dynamics in urinary bladder smooth muscle from transgenic mice overexpressing Na+-ca2+ exchanger
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نویسنده
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murata h. ,hotta s. ,sawada e. ,yamamura h. ,ohya s. ,kita s. ,iwamoto t. ,imaizumi y.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 3 - صفحه:373 -377
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چکیده
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The rise of ca 2+ concentration ([ca 2+] i) by reducing external na + in urinary bladder smooth muscle cells (ubsmcs) from transgenic mice overexpressing na + /ca 2+ exchanger type- 1.3 (ncx1.3 tg/tg) was about 4 times as large as that in the wild-type (wt). ncx1 protein expression in ub increased about 4-fold in ncx1.3 tg/tg. the ca 2+ release by caffeine in ubsmcs was comparable between ncx1.3 tg/tg and wt,but [ca 2+] i decay was faster in ncx1.3 tg/tg. contractions induced by acetylcholine,60 mm k +,or electrical stimulation were significantly smaller in ub segments of ncx1.3 tg/tg. ncx worked in ca 2+ -extrusion mode during these contractions in ubsmcs of both wt and ncx1.3 tg/tg. © 2010 the japanese pharmacological society.
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کلیدواژه
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Na+-Ca2+ exchanger; Transgenic mouse; Urinary bladder smooth muscle
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آدرس
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department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan, department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan, department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan, department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan, department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan, department of pharmacology,school of medicine,fukuoka university,fukuoka 814-0180, Japan, department of pharmacology,school of medicine,fukuoka university,fukuoka 814-0180, Japan, department of molecular and cellular pharmacology,graduate school of pharmaceutical sciences,nagoya city university,nagoya 467-8603, Japan
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Authors
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