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Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats
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نویسنده
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masuda t. ,hirabara y. ,nakamura y. ,chishaki a. ,tsuruhisa m. ,miyakawa m. ,honda k. ,saito r. ,sakamoto h. ,kawata m. ,takano y.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 112 - شماره : 4 - صفحه:482 -486
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چکیده
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We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (nts) in the arterial baroreceptor reflex (baroreflex) function. baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. this baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (mr) antagonist eplerenone into the nts. 11β-hydroxysteroid dehydrogenase type 2 neurons and mr were also identified in the nts. these data suggest that the aldosterone-sensitive neurons in the nts may have an impor-tant role in baroreflex function. ©2010 the japanese pharmacological society.
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کلیدواژه
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Aldosterone-sensitive nucleus tractus solitarius (NTS) neuron; Arterial baroreceptor reflex; Mineralocorticoid (MR) antagonist eplerenone
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آدرس
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department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180,japan,department of pharmacy,university miyazaki hospital,miyazaki 889-1692, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan, department of anatomy and neurobiology,kyoto prefectural university of medicine,kyoto 602-8566,japan,ushimado marine laboratory,graduate school of natural science and technology okayama university,okayama 701-4303, Japan, department of anatomy and neurobiology,kyoto prefectural university of medicine,kyoto 602-8566, Japan, department of physiology and pharmacology,faculty of pharmaceutical sciences,fukuoka university,fukuoka 814-0180, Japan
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Authors
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