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A novel chemoattractant lectin,karatoxin,from the dorsal spines of the small scorpionfish Hypodytes rubripinnis
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نویسنده
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shinohara m. ,nagasaka k. ,nakagawa h. ,edo k. ,sakai h. ,kato k. ,iwaki f. ,ohura k. ,sakuraba h.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 113 - شماره : 4 - صفحه:414 -417
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چکیده
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A chemoattractant lectin from the dorsal spines of the redfin velvetfish,hypodytes rubripinnis,was isolated using a combination of affinity chromatography techniques. the glycoprotein,with a molecular mass of 110 kda,is named karatoxin. karatoxin caused agglutination of rabbit erythrocytes. this agglutination was effectively inhibited by d-mannose. in addition,karatoxin exhibited not only mitogenic activity in the presence of murine splenocytes,but also chemotactic activity in the presence of guinea-pig neutrophils and macrophages. thus,karatoxin appears to be a novel chemoattractant lectin. these results suggest that the redfin velvetfish hypodytes rubripinnis may be a novel source of biologically active substances. © 2010 the japanese pharmacological society.
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کلیدواژه
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Chemoattractant lectin; Hypodytes rubrinnis; Karatoxin
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آدرس
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depatment of pharmacology,osaka dental university,hirakata 573-1121, Japan, fukae nagasaka clinic,etajima 737-2214, Japan, depatment of pharmacology,osaka dental university,hirakata 573-1121,japan,department of environmental symbiosis,institute of socio-arts and sciences,the university of tokushima graduate school,tokushima 770-8502, Japan, department of environmental symbiosis,institute of socio-arts and sciences,the university of tokushima graduate school,tokushima 770-8502, Japan, department of environmental symbiosis,institute of socio-arts and sciences,the university of tokushima graduate school,tokushima 770-8502, Japan, depatment of pharmacology,osaka dental university,hirakata 573-1121, Japan, depatment of pharmacology,osaka dental university,hirakata 573-1121, Japan, depatment of pharmacology,osaka dental university,hirakata 573-1121, Japan, department of applied biological sciences,kagawa university,kagawa 761-0795, Japan
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Authors
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