Parishin C attenuates phencyclidine-induced schizophrenia-like psychosis in mice: Involvements of 5-HT1A receptor

Parishin c,a major component of gastrodia elata b lume (ge),was purified from ge. because ge modulates the serotonergic system and the 5-ht1a receptor is an important therapeutic target of schizophrenia,we examined whether parishin c affects phencyclidine-induced abnormal behaviors in mice. phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin c. these effects were reversed by way 100635,a 5-ht1a-receptor antagonist. consistently,parishin c showed high affinity at 5-ht1a receptor as well as a 5-ht1a-agonist activity in a 8-oh-dpat-stimulated [35 s]gtp-γs binding assay. our results suggest that the antipsychotic effects of parishin c require activation of 5-ht1a receptors. © 2010 the japanese pharmacological society.