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Concentration-dependent inhibitory effect of irbesartan on renal uric acid transporters
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نویسنده
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nakamura m. ,anzai n. ,jutabha p. ,sato h. ,sakurai h. ,ichida k.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 114 - شماره : 1 - صفحه:115 -118
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چکیده
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Hyperuricemia is currently recognized as a risk factor for cardiovascular diseases. it has been reported that the angiotensin ii-receptor blocker (arb) losartan decreases serum uric acid level. in this study,the effects of another arb,irbesartan,on [14c]uric acid-transport activity of renal uric acid reabsorptive transporters urat1 and uratv1 were examined with xenopus oocytes expressing each transporter. the results showed that irbesartan (100 - 500 μm) inhibited the uptake of uric acid via both transporters. the inhibitory effects of irbesartan exceeded those of losartan and other arbs,and the results suggest that irbesartan can reduce serum uric acid level. ©2010 the japanese pharmacological society.
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کلیدواژه
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Angiotensin II-receptor blocker; Transporter; Uric acid
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آدرس
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department of pathophysiology,tokyo university of pharmacy and life sciences,tokyo 192-0392, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, department of pathophysiology,tokyo university of pharmacy and life sciences,tokyo 192-0392, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, department of pathophysiology,tokyo university of pharmacy and life sciences,tokyo 192-0392, Japan
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Authors
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