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TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress
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نویسنده
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hosoi t. ,tamubo t. ,horie n. ,okuma y. ,nomura y. ,ozawa a.k.
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منبع
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journal of pharmacological sciences - 2010 - دوره : 114 - شماره : 2 - صفحه:230 -233
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چکیده
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Endoplasmic reticulum (er) stress has been implicated in the pathogenesis of diseases such as neurodegenerative disease. in the present study,we established the er stress-resistant sh-sy5y cell line,and through microarray analysis,we found that tek/tie2 expression is upregulated in this cell line. moreover,we found that tek/tie2 expression was markedly decreased in er-stressed cells. the effect was time-dependent (2 - 24 h),which began to decrease from 2-h time point. our findings suggest that tek/tie2 expression is involved in cell survival,whereas when severe er stress occurs,tek/tie2 expression is down-regulated,resulting in cell death. © 2010 the japanese pharmacological society.
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کلیدواژه
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Akt; Microarray; Neurodegenerative disease
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آدرس
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department of pharmacotherapy,graduate school of biomedical sciences,hiroshima university,kasumi 1-2-3,minami-ku,hiroshima 734-8551, Japan, department of pharmacotherapy,graduate school of biomedical sciences,hiroshima university,kasumi 1-2-3,minami-ku,hiroshima 734-8551, Japan, department of pharmacology,graduate school of pharmaceutical sciences,hokkaido university,kita 12,nishi 6,kita-ku,sapporo 060-0812, Japan, department of pharmacology,faculty of pharmaceutical sciences,chiba institute of sciences,3 shiomi-cho,choshi,chiba 288-0025, Japan, department of pharmacotherapeutics,yokohama college of pharmacy,601 matano-cho,totsuka-ku,yokohama 245-0066, Japan, department of pharmacotherapy,graduate school of biomedical sciences,hiroshima university,kasumi 1-2-3,minami-ku,hiroshima 734-8551, Japan
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Authors
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