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Biphasic tracheal relaxation induced by higenamine and nantenine from Nandina domestica THUNBERG
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نویسنده
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ueki t. ,akaishi t. ,okumura h. ,morioka t. ,abe k.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 115 - شماره : 2 - صفحه:254 -257
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چکیده
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We compared the effects of the extract from fruits of nandina domestica thunberg (nde) and its constituents,higenamine and nantenine,on contractile responses in isolated guineapig trachea. nde (1 mg/ml) caused biphasic relaxation of the trachea precontracted with high-k+ stimulation: the fast component was blocked by propranolol and mimicked by higenamine; and the slow was resistant to propranolol and mimicked by nantenine. ca 2+-induced contraction under high-k+ stimulation was antagonized by nantenine or nde + propranolol. these results suggest that nde relaxes the trachea quickly through β-adrenoceptor stimulation by higenamine and slowly through ca2+ antagonism by nantenine. © the japanese pharmacological society.
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کلیدواژه
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Higenamine; Nandina domestica THUNBERG; Tracheal relaxation
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آدرس
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faculty of pharmacy,research institute of pharmaceutical sciences,musashino university,tokyo 202-8585,japan,tokiwa pharmaceutical co.,ltd.,3-5-12 azuchimachi,chuo-ku,osaka 541-0052, Japan, faculty of pharmacy,research institute of pharmaceutical sciences,musashino university,tokyo 202-8585, Japan, tokiwa pharmaceutical co.,ltd.,3-5-12 azuchimachi,chuo-ku,osaka 541-0052, Japan, tokiwa pharmaceutical co.,ltd.,3-5-12 azuchimachi,chuo-ku,osaka 541-0052, Japan, faculty of pharmacy,research institute of pharmaceutical sciences,musashino university,tokyo 202-8585, Japan
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Authors
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