|
|
|
|
Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms
|
|
|
|
|
|
|
|
نویسنده
|
jutabha p. ,anzai n. ,kimura t. ,taniguchi a. ,urano w. ,yamanaka h. ,endou h. ,sakurai h.
|
|
منبع
|
journal of pharmacological sciences - 2011 - دوره : 115 - شماره : 2 - صفحه:249 -253
|
|
چکیده
|
We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (snps) in the sodium-phosphate transporter npt4 gene (slc17a3) using the xenopus oocyte expression system. npt4 variants carrying snp v257f,g279r,or p378l exhibited reduced transport of [14c]para- aminohippurate,[3h]bumetanide,[3h]estrone sulfate,and [14c]urate,when each variant clone was expressed in the plasma membrane of oocytes. this study suggests the possibility that the genetic variation of npt4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate. © the japanese pharmacological society.
|
|
کلیدواژه
|
Diuretic; Single nucleotide polymorphism; Urate
|
|
آدرس
|
department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, institute of rheumatology,tokyo women's medical university,tokyo 162-0054, Japan, institute of rheumatology,tokyo women's medical university,tokyo 162-0054, Japan, institute of rheumatology,tokyo women's medical university,tokyo 162-0054, Japan, institute of rheumatology,tokyo women's medical university,tokyo 162-0054, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan, department of pharmacology and toxicology,kyorin university school of medicine,tokyo 181-8611, Japan
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|