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Na+/Ca2+ exchanger inhibitors inhibit neurite outgrowth in PC12 cells
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نویسنده
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oda t. ,kume t. ,izumi y. ,ishihara k. ,sugmimoto h. ,akaike a.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 116 - شماره : 1 - صفحه:128 -131
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چکیده
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To elucidate the role of na+/ca2+ exchanger (ncx) in neurite outgrowth,we investigated the effects of ncx inhibitors on neurite outgrowth in pc12 cells. kb-r7943 and 3′,4′-dichlorobenzamil,ncx inhibitors,inhibited the neurite outgrowth caused by nerve growth factor (ngf). ncx inhibitors inhibited the neurite outgrowth caused by dibutylyl camp,which rapidly reorganizes the cytoskeleton. kb-r7943 inhibited the neurite outgrowth caused by y-27632,an inhibitor of rho kinase (rock) that regulates actin. however,ncx inhibitors did not inhibit ngf-induced phosphorylation of extracellular signal-regulated kinase. these results suggest that ncx inhibitor affects downstream of the rho-rock signal transduction pathways in neurite outgrowth. © the japanese pharmacological society.
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کلیدواژه
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Na+/Ca2+ exchanger (NCX); Neurite outgrowth; PC12
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آدرس
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department of pharmacology,graduate school of pharmaceutical sciences,kyoto university,sakyo-ku,kyoto 606-8501,japan,laboratory of neuropharmacology,faculty of pharmaceutical sciences,hiroshima international university,5-1-1 hirokoshingai,kure,hiroshima 737-0112, Japan, department of pharmacology,graduate school of pharmaceutical sciences,kyoto university,sakyo-ku,kyoto 606-8501, Japan, department of pharmacology,graduate school of pharmaceutical sciences,kyoto university,sakyo-ku,kyoto 606-8501, Japan, laboratory of neuropharmacology,faculty of pharmaceutical sciences,hiroshima international university,5-1-1 hirokoshingai,kure,hiroshima 737-0112, Japan, world-leading drug discovery research center,graduate school of pharmaceutical sciences,kyoto university,46-29 yoshida-shimoadachi-cho,sakyo-ku,kyoto 606-8501, Japan, department of pharmacology,graduate school of pharmaceutical sciences,kyoto university,sakyo-ku,kyoto 606-8501, Japan
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Authors
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