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Measurements of cardiac ion channel subunits in the chronic atrioventricular block dog
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نویسنده
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takahara a. ,wagatsuma h. ,aritomi s. ,konda t. ,akie y. ,nakamura y. ,sugiyama a.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 116 - شماره : 1 - صفحه:132 -135
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چکیده
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The chronic atrioventricular block (cavb) dog has been widely used as an in vivo proarrhythmia model. mrna levels of k+ and ca2+ channels in the isolated ventricular tissues from normal and cavb dogs were assayed using a real-time pcr. the mrna levels of kvlqt1 and mirp1 were significantly less in the cavb heart compared with those in the intact heart,whereas no significant difference was detected in the mrna levels of other k+- or ca2+-channel subunits. adaptation against chronic bradycardia-related pathophysiology may have decreased the mrna levels of cardiac k+ channels,which may partly explain the arrhythmogenic property of this model. © the japanese pharmacological society.
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کلیدواژه
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Chronic atrioventricular block; Ion-channel subunit; mRNA
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آدرس
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department of clinical pharmacy,faculty of pharmaceutical sciences,toho university,funabashi,chiba 274-8510, Japan, research center,ajinomoto pharmaceuticals,kawasaki,kanagawa 210-8681, Japan, research center,ajinomoto pharmaceuticals,kawasaki,kanagawa 210-8681, Japan, research center,ajinomoto pharmaceuticals,kawasaki,kanagawa 210-8681, Japan, sugi institute of biological science,hokuto,yamanashi 408-0044,japan,department of pharmacology,school of medicine,toho university,tokyo 143-8540, Japan, department of pharmacology,school of medicine,toho university,tokyo 143-8540, Japan, department of pharmacology,school of medicine,toho university,tokyo 143-8540, Japan
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Authors
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