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Neuropsychotoxic and neuroprotective potentials of dextromethorphan and its analogs
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نویسنده
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shin e.-j. ,bach j.-h. ,lee s.y. ,kim j.m. ,lee j. ,hong j.-s. ,nabeshima t. ,kim h.-c.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 116 - شماره : 2 - صفحه:137 -148
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چکیده
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Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. although some of these effects are neuropsychotoxic,this review focuses on the neuroprotective effects of dextromethorphan and its analogs. some of these analogs,particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan,have promising neuroprotective properties with negligible neuropsychotoxic effects. their neuroprotective effects,the mechanisms underlying these effects,and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed. © the japanese pharmacological society.
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کلیدواژه
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3-Hydroxymorphinan; Dextromethorphan; Dimemorfan; Neurodegenerative disorder; Neuroprotection; Neuropsychotoxicity
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آدرس
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neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon 200-701, South Korea, neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon 200-701, South Korea, neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon 200-701, South Korea, central research center,green cross corp.,yongin 446-799, South Korea, central research center,green cross corp.,yongin 446-799, South Korea, laboratory of pharmacology and chemistry,national institute of environmental health sciences,national institutes of health,research triangle park,nc 27709, United States, department of pharmacology,graduate school of pharmaceutical sciences,meijo university,nagoya 468-8503, Japan, neuropsychopharmacology and toxicology program,college of pharmacy,kangwon national university,chunchon 200-701, South Korea
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Authors
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