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Anti-neuroinflammatory activity of kamebakaurin from Isodon japonicus via inhibition of c-Jun NH 2-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells
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نویسنده
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kim b.-w. ,koppula s. ,kim i.s. ,lim h.-w. ,hong s.-m. ,han s.-d. ,hwang b.-y. ,choi d.-k.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 116 - شماره : 3 - صفحه:296 -308
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چکیده
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Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. therefore,quelling of microglial activation may lead to neuronal cell survival. the present study investigated the effects of kamebakaurin (kmbk),a kaurane diterpene isolated from isodon japonicus hara (labiatae),on the production of pro-inflammatory mediators in lipopolysaccharide (lps)-stimulated cytotoxicity in rat primary microglial cultures and the bv-2 cell line. kmbk significantly inhibited the lps-induced production of nitric oxide (no) in a concentration-dependent fashion in activated microglial cells. the mrna and protein levels of inducible nitric oxide synthase (inos) and cyclooxycenase-2 (cox-2) were also decreased dose-dependently. furthermore kmbk inhibited the jnk and p38 mitogen-activated protein kinases (mapks) in lps-stimulated bv-2 microglial cells. considering the results obtained,the present study authenticated the potential benefits of kmbk as a therapeutic target in ameliorating microglia-mediated neuroinflammatory diseases. © the japanese pharmacological society.
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کلیدواژه
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Inducible nitric oxide synthase; Kamebakaurin; Microglia; Neuroinflammation; Nitrite
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آدرس
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department of biotechnology,konkuk university,chungju 380-701, South Korea, department of biotechnology,konkuk university,chungju 380-701, South Korea, department of biotechnology,konkuk university,chungju 380-701, South Korea, department of biotechnology,konkuk university,chungju 380-701, South Korea, department of biotechnology,konkuk university,chungju 380-701, South Korea, department of neurology,school of medicine,konkuk university,chungju 380-704, South Korea, college of pharmacy and medical research center (cict),chungbuk national university,cheongju 361-763, South Korea, department of biotechnology,konkuk university,chungju 380-701, South Korea
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Authors
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