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A novel human organic anion transporter NPT4 mediates the transport of ochratoxin A
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نویسنده
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jutabha p. ,anzai n. ,hayashi k. ,domae m. ,uchida k. ,endou h. ,sakurai h.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 116 - شماره : 4 - صفحه:392 -396
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چکیده
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In the present study,we investigated the transport of nephrotoxic mycotoxin ochratoxin a (otxa) by a novel human organic anion transporter hnpt4 using the xenopus oocyte expression system. hnpt4 mediated time- and concentration-dependent uptake of otxa (k m: 802.8 μm) in a ph- and voltage-sensitive manner. cis-inhibition experiments suggest that the substrate selectivity of hnpt4 is similar to that of hoat4. the fact that the k m of otxa for the efflux transporter hnpt4 was much higher than those for the uptake transporters hoat1 and hoat3 may favor the accumulation of otxa in the tubular cell and lead to nephrotoxicity. © the japanese pharmacological society.
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کلیدواژه
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Nephrotoxicity; Ochratoxin A; Organic anion transporter
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آدرس
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department of pharmacology and toxicology,kyorin university,school of medicine,tokyo 181-8611, Japan, department of pharmacology and toxicology,kyorin university,school of medicine,tokyo 181-8611,japan,department of pharmacology and toxicology,dokkyo medical university,school of medicine,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university,school of medicine,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university,school of medicine,tochigi 321-0293, Japan, department of pharmacology and toxicology,dokkyo medical university,school of medicine,tochigi 321-0293, Japan, department of pharmacology and toxicology,kyorin university,school of medicine,tokyo 181-8611, Japan, department of pharmacology and toxicology,kyorin university,school of medicine,tokyo 181-8611, Japan
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Authors
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