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Expression of the ubiquitin ligase HRD1 in neural stem/progenitor cells of the adult mouse brain
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نویسنده
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kawada k. ,kaneko m. ,nomura y. ,mimori s. ,hamana h. ,ogita k. ,murayama t. ,fujino h. ,okuma y.
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منبع
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journal of pharmacological sciences - 2011 - دوره : 117 - شماره : 3 - صفحه:208 -212
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چکیده
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Neural stem/progenitor cells (nscs) reside in the subventricular zone (svz) and subgranular zone of the hippocampal dentate gyrus in adult mammals. the ubiquitin ligase hrd1 is associated with degradation of amyloid precursor protein and believed to be specifically expressed in neurons and not in astrocytes. we investigated expression of hrd1 using immunohistochemistry and found colocalization of hrd1 with the nsc marker protein nestin and glial fibrillary acidic protein in the nscs of the svz (the svz astrocytes) but not in the hippocampus. in the hippocampal dentate gyrus,hrd1 is localized in the nucleus of nestin-positive cells. © the japanese pharmacological society.
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کلیدواژه
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Hippocampus; HRD1; Subventricular zone
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آدرس
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department of pharmacology,faculty of pharmaceutical sciences,chiba institute of science,choshi,chiba 288-0025, Japan, department of pharmacology,faculty of pharmaceutical sciences,chiba institute of science,choshi,chiba 288-0025, Japan, laboratory of pharmacotherapeutics,yokohama college of pharmacy,yokohama,kanagawa 245-0066, Japan, department of pharmaceutical chemistry,faculty of pharmaceutical sciences,chiba institute of science,choshi,chiba 288-0025, Japan, department of pharmaceutical chemistry,faculty of pharmaceutical sciences,chiba institute of science,choshi,chiba 288-0025, Japan, department of pharmacology,faculty of pharmaceutical sciences,setsunan university,hirakata,osaka 573-0101, Japan, laboratory of chemical pharmacology,graduate school of pharmaceutical sciences,chiba university,chiba 260-8675, Japan, laboratory of chemical pharmacology,graduate school of pharmaceutical sciences,chiba university,chiba 260-8675, Japan, department of pharmacology,faculty of pharmaceutical sciences,chiba institute of science,choshi,chiba 288-0025, Japan
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Authors
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