>
Fa   |   Ar   |   En
   Down-regulation of myosin light chain kinase expression in vascular smooth muscle cells accelerates cell proliferation: Requirement of its actin-binding domain for reversion to normal rates  
   
نویسنده wang h.h. ,nakamura a. ,yoshiyama s. ,ishikawa r. ,cai n. ,ye l.-h. ,takano-ohmuro h. ,kohama k.
منبع journal of pharmacological sciences - 2012 - دوره : 119 - شماره : 1 - صفحه:91 -96
چکیده    Myosin light-chain kinase (mlck) is a multi-domain protein with kinase and actin-binding domains,among others. deficiency of mlck expression in gbasm-4 vascular smooth muscle cells enhanced cell proliferation rate and shortened cell doubling time. transient transfection of the mlck-deficient cells with cdna constructs of either wild-type mlck or its mutant lacking the kinase activity reverted the cell proliferation rate to that of wild-type cells,whereas that of mlck lacking the actin-binding domain maintained cell proliferation at an elevated rate similar to the mlck-deficient cells. thus,the actin-binding domain of mlck seems to play a role in regulating cell proliferation. © the japanese pharmacological society.
کلیدواژه Actin-binding domain; Myosin light-chain kinase; Vascular smooth muscle proliferation
آدرس department of molecular and cellular pharmacology,gunma university graduate school of medicine,gunma 371-8511, Japan, department of molecular and cellular pharmacology,gunma university graduate school of medicine,gunma 371-8511, Japan, department of molecular and cellular pharmacology,gunma university graduate school of medicine,gunma 371-8511, Japan, department of molecular and cellular pharmacology,gunma university graduate school of medicine,gunma 371-8511, Japan, department of biochemistry,college of life sciences,nankai university,tianjin 300071, China, department of biochemistry,college of life sciences,nankai university,tianjin 300071, China, research institute of pharmaceutical sciences,musashino university,nishitokyo,tokyo 202-8585, Japan, department of molecular and cellular pharmacology,gunma university graduate school of medicine,gunma 371-8511,japan,research institute of pharmaceutical sciences,musashino university,nishitokyo,tokyo 202-8585, Japan
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved